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Our Research

Cell Identity

Our principal axis of research activity is centred on the relationshion between cell fate acquisition and the cell cycle.

Development study

The links between cell fates and cell proliferation are essential for defining the mechanisms that underlie development processes.

News

Nos travaux sur la dynamique de la division cellulaire des cellules précurseurs des organes mécanosensoriels ont été publiés dans eLife. Cette très jolie étude, qui va de la génétique à l’analyse comportementale, montre l’existence d’une vague mitotique des précurseurs au sein de l’épithélium. Il est en faveur de l’idée que le temps est un paramètre du développement du système nerveux, et pas seulement une dimension dans laquelle le développement se produit.

A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology (2022)

Lacoste, J., Soula, H., Burg, A., Audibert, A., Darnat, P., Gho, M., & Louvet-Vallée, S. eLife 7 mars 2022.

https://elifesciences.org/articles/75746

See our new article in Genetics on the role of the transcription factor Tramtrack69 in the coordination between proliferation and acquisition of cell identity. We show that Ttk69 plays a central role in the formation of neural cell lines by integrating molecular mechanisms regulating progenitor cell-cycle exit and cell-fate commitment. Simon F, Ramat A, Louvet-Vallée S, Lacoste J, Burg A, Audibert A, Gho M (2019) Shaping of Drosophila neural cell lineages through coordination of cell proliferation and cell fate by the BTB-ZF transcription factor Tramtrack-69. Genetics. 212; 773-788.

Our Team

Contact Us

Are you looking for an internship in Master, PhD thesis or Postoctoral studies? Are you interested in our research? Are you motivated?

Où sommes-nous ?

Our laboratory is located on the campus Pierre and Marie Curie, Paris 5th.

Call us

Michel Gho +01 44 27 22 49

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