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Escargot and Scratch, two transcription regulators belonging to the Snail family, redundantly repress N-gene target transcription and, as such, maintain a silenced N-pathway in neural precursor cells. Learn more

G2-phase arrest in sensory organ precursor cells promotes formation of sensory organs containing the correct number of sensory cells by 1) preventing the division of precursor cells following a self-renewal mode and 2) synchronizing cell division with developmental signals that induce neural cell fates. Learn more

the Notch-pathway, the main signalling pathway in these organs, and Prospero, a fate determinant, maintain the terminal cells in a quiescent state. As such, in terminal cells, fate acquisition and cell cycle progression are regulated by two parallel mechanisms acting simultaneously. Learn more
cells are more sensitive to Notch when this pathway is activated during the S-phase than during the G2-phase. Our evidence suggests that this S-dependent cell responsiveness is due to a local de-compacted chromatin state during DNA replication. Learn more
Cyclin-A, contrary to current belief, is involved in endocycle dynamics in Drosophila. In addition, we show that CycA controls DNA-replication via a subnuclear relocalisation of pre-replication complex. Learn more
it is possible to obtain a significant RNA sample from precursor cells isolated by laser microdissection from fixed tissue. This allows us to successful characterize the transcriptional profile of precursor cells identified at a precise moment of development. Learn more

 Étude des relations entre l’acquisition du and the cell cycle.

Plus particulièrement, nous nous intéressons au contrôle temporel de la mise en place de l’identité cellulaire dans des cellules en prolifération. Ainsi les questions que nous posont sont: Comment est déterminée l’identité cellulaire au cours du temps? Comment la prolifération cellulaire et l’identité cellulaire sont-elles coordonnées? Comprendre les liens complexes qui existent entre acquisition du destin cellulaire et prolifération cellulaire est essentiel pour définir les mécanismes qui sont à la base des processus du développement ainsi que ceux générant diverses pathologies. Nous utilisons la drosophile comme modèle pour aborder cette problématique en combinant des approches de génétique, de biologie cellulaire et moléculaire ainsi qu’une méthodologie d’imagerie en temps réel. Nous utilisons principalement le lignage des soies (plus de détails, click here) that gives rise to externally sensory organs on the thorax of the fly. Our work underlines the notion that developmental regulated cell lineages are more complex than a simple branching pattern of a lineage tree. The identity of progenitor cells changes over time independently of cell divisions. Cell proliferation and cell determination are associated with different variants of the cell cycle. Since the capacity to respond to determinant pathways varies according to the phase of the cell cycle, there is an interplay between the control of the cell cycle, cell responsiveness and the acquisition of cell identity that shape the lineages. This interplay defines the generation, at precise developmental time points, of a given number of unique cell types. Due to the evolutionary conservation of basic biological processes, the principles of cell lineage shaping that we have revealed are likely to be extensively conserved in animal development.